Screenflow 3 is hands down the best $99 bucks I ever spent on software. Simple as that. Records the whole screen, multiple audio source ( computer and microphone) and captures the isight camera for picture in picture. Mac Only!
No doubt if your doing your homework on this product you will of come across Techsmith’s Camtasia Studio. Well there new version is number 7 and while I own version 6 for my PC I hardly ever use my PC now for creating screencasts.